Effects of Pulsed Electromagnetic Fields on Interleukin – 1 Beta and Postoperative Pain: A Double-Blind, Placebo-Controlled, Pilot Study in Breast Reduction Patients

Journal: Plastic and Reconstructive Surgery
Publication Date: 1 June 2010
Authors: Christine Rohde, Austin Chiang, Omotinuwe Adipoju, Diana Casper, Arthur A Pilla

A 2010 double-blind, placebo-controlled pilot study evaluated the effects of pulsed electromagnetic field (PMF) therapy on post-operative pain and recovery in 24 patients undergoing breast reduction surgery. PEMF was used after surgery, and its effects were measure by tracking pain levels, narcotic use, and mean IL-1 beta concentration in wound exudates.

  • Pain reduction: 57% decrease at 1 hour (p < 0.01) and 300% decrease at 5 hours (p < 0.001) compared to sham device
  • Il-1 beta concentration: Mean IL-1 beta concentration was 275% lower in the wound exudates of treated patients (p < 0.001)
  • Narcotic use: 2.2-fold reduction in opioid consumption in the active group (p = 0.002)


These findings suggest that PEMF may reduce postoperative pain and inflammation while decreasing the need for narcotics.

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